Non-invasive dynamic monitoring of cerebral edema in patients with herpes simplex virus encephalitis

The study is aimed to investigate a non-invasive method for dynamic monitoring of cerebral edema in patients with herpes simplex virus encephalitis (HSVE). We evaluated the utility of the method in 100 patients with intracerebral hemorrhage and 40 patients with HSVE. The agitating coefficient (AC) was dynamically monitored from day 1 to day 12 using a non-invasive cerebral edema dynamic monitor. The AC positive rate of HSVE patients was 75.5%. The lesion located in temporal lobe had the highest AC positive rate, while those with an encephalitis lesion volume of < 20 ml had low positive rate. On day 1 after hospital admission, the AC of HSVE patients was higher than that of the healthy side, which increased gradually and reached the peak value on day 5. Afterwards, the value decreased gradually, which continued until day 11 and then became normal. After clinical use of mannitol, the AC value of encephalitis patients decreased to different extent. Non-invasive cerebral edema dynamic monitor can dynamically monitor the development of cerebral edema in HSVE patients.